Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun genetics A
matrix ofenzymes that is the site ofDNA replication in thenucleus of acell
Etymologies
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Examples
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"This discovery may explain the decades-old dilemma between work from the 1970s that observed discontinuous synthesis on the leading and lagging strands, and the current semidiscontinuous model in the textbooks based on studies of replisome mechanisms outside the context of a living cell, that is, without concurrent transcription," O'Donnell says.
PhysOrg.com - latest science and technology news stories 2010
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In addition, the research provides more evidence that the replisome is sturdy and does not fall apart when it hits a road block, as some experiments had suggested.
PhysOrg.com - latest science and technology news stories 2010
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The replisome made even more full-length copies of the DNA when Mfd was present, suggesting the protein helps give RNA polymerase the boot in their experimental system as well.
PhysOrg.com - latest science and technology news stories 2010
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As the two strands separate, the replisome copies the strands, producing two complete sets of the genome.
PhysOrg.com - latest science and technology news stories 2010
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But the consequences would be dire if the replisome fell apart every time it met an RNA polymerase.
PhysOrg.com - latest science and technology news stories 2010
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They developed a system that allowed them to assemble the replisome from the relatively simple bacteria Escherichia coli at one end of a DNA strand - a years-long endeavor in O'Donnell's lab - and then set it on a collision course with a stalled RNA polymerase from the opposite direction.
PhysOrg.com - latest science and technology news stories 2010
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He'd also like to know whether the replisome in eukaryotic cells, such as yeast or mammalian cells, behaves similarly to the bacterial complex he and Pomerantz have studied.
PhysOrg.com - latest science and technology news stories 2010
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In the earlier work, the researchers found that the replisome displaced RNA polymerase but used the messenger RNA to continue leading strand synthesis.
PhysOrg.com - latest science and technology news stories 2010
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O'Donnell is now searching for factors other than Mfd that push the replisome through blocks.
PhysOrg.com - latest science and technology news stories 2010
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The experiments illustrate a new role for Mfd enabling the replisome to move past an RNA polymerase block and effectively copy DNA, which could have implications for understanding the disorder, O'Donnell says.
PhysOrg.com - latest science and technology news stories 2010
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