from the GNU version of the Collaborative International Dictionary of English.
- (Chem. & Med.) A chemical substance (C17H14O4S, molecular weight 314.36) used in medicine as an analgesic to alleviate pain and inflammation; it is a synthetic compound, and is marketed by Merck & Co. under the trade name
Vioxx, in tablets giving dosages of 12.5 or 25 milligrams. It is classed as a non-steroidal anti-inflammatory drug (NSAID). Chemically, it is 4-[4-(methylsulfony)phenyl]-3-phenyl-2(5H) furanone. Its chemical structure contains two phenyl rings and a furanone ring. It is believed to act by inhibition of prostaglandin biosynthesis, through inhibition of the enzyme cyclooxygenase-2 (COX-2); unlike aspirin, it does not inhibit cyclooxygenase-1.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A particular
nonsteroidal anti-inflammatory drug.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004
Sorry, no etymologies found.
The drugs were naproxen, ibuprofen, diclofenac, celecoxib, etoricoxib and two others not used in England, called rofecoxib or Vioxx, and lumiracoxib.
They further pointed out in a press release alternatives such as rofecoxib and valdecoxib increase the rise of cardiovascular dysfunctions, including stroke.
Although medications that studies show posed the highest risk, including rofecoxib (Vioxx) and valdecoxib (Bextra), were banned or removed from the U.S. market, many NSAIDs with identified risks, such as prescription-only celecoxib (Celebrex), still are on the market.
Highest risk of miscarriage was associated with diclofenac and lowest risk with rofecoxib.
People who thought they were in the clear after they stopped taking the now banned painkiller rofecoxib Vioxx might have to think again.
The benefits were much the same as other anti-inflammatory painkillers, which sold for a fraction of the cost, but Vioxx the generic name is rofecoxib was designed to be less irritating to people's stomachs than older drugs in this class, cutting the risk of potentially dangerous internal bleeding.
The Vioxx (rofecoxib) debacle, for instance, highlighted why phase IV trials matter.
The benefits were much the same as other anti-inflammatory painkillers, which sold for a fraction of the cost, but Vioxx (the generic name is rofecoxib) was designed to be less irritating to people's stomachs than older drugs in this class, cutting the risk of potentially dangerous internal bleeding.
The Journal's editors write: "The information we have indicates that the VIGOR article, because it did not contain relevant safety data available to the authors more than four months before publication, did not accurately reflect the potential for serious cardiovascular toxicity with rofecoxib Vioxx."
The molecular structures for Vioxx (rofecoxib)and Celebrex (celecoxib) are very similar (as inferred from their generic names "-coxib").