Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun medicine A drug currently (2006) on trial for the treatment of leukemia, herpes and HIV infection

Etymologies

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Examples

  • With one drug - roscovitine, currently in clinical trials for an unrelated ailment - a regular heartbeat was restored.

    The Seattle Times 2011

  • (B) Endogenous raptor is phosphorylated on Thr706 in synchronized cells undergoing mitosis, and this phosphorylation is blocked by the CDK inhibitor roscovitine.

    PLoS ONE Alerts: New Articles Dana M. Gwinn et al. 2010

  • Seliciclib (CYC202 or R-roscovitine), a CDK (cyclin dependent kinase) inhibitor, is in Phase 2 studies for the treatment of lung cancer and nasopharyngeal cancer and in a Phase 1 trial in combination with sapacitabine.

    News 2010

  • Seliciclib (CYC202 or R-roscovitine), a CDK (cyclin dependent kinase) inhibitor, is in Phase 2 studies for the treatment of lung cancer and nasopharyngeal cancer and in a Phase 1 trial in combination with sapacitabine.

    News 2010

  • Seliciclib (CYC202 or R-roscovitine), a CDK (cyclin dependent kinase) inhibitor, is in Phase 2 studies for the treatment of lung cancer and nasopharyngeal cancer and in a Phase 1 trial in combination with sapacitabine.

    News 2010

  • (D) Hela cells stably expressing myc-raptor (wt or 3A) with stable knockdown of endogenous raptor were treated with nocodazole for 16 hours, then Torin1 or roscovitine were added for 4 hours.

    PLoS ONE Alerts: New Articles Dana M. Gwinn et al. 2010

  • "We challenged the aromatase-overexpressing cells with either the wild-type or the low forms of cyclin E and then treated them with the CDK2 inhibitor roscovitine," Keyomarsi said.

    PhysOrg.com - latest science and technology news stories 2010

  • Eight to ten hours later, 2 mM thymidine was added again for 14-16 hours, cells were washed twice with PBS, then released into thymidine-free media. 50 uM roscovitine was administered for 6 hours following 16 hours nocodazole treatment in A549 cells.

    PLoS ONE Alerts: New Articles Dana M. Gwinn et al. 2010

  • We further examined cdc2 involvement through acute treatment of nocodazole arrested cells with the cdc2 inhibitor roscovitine.

    PLoS ONE Alerts: New Articles Dana M. Gwinn et al. 2010

  • "We challenged the aromatase-overexpressing cells with either the wild-type or the low forms of cyclin E and then treated them with the CDK2 inhibitor roscovitine," Keyomarsi said.

    THE MEDICAL NEWS Editors 2010

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