from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. An protein kinase inhibitor derived from the kamala tree (Mallotus philippinensis)

from The Century Dictionary and Cyclopedia

  • n. A flesh-colored or yellow crystalline dyestuff, (C11H10O3)3 obtained from Echinus Philippinensis. It is the active constituent of the vermifuge kamila. Also called mallotoxin.


Sorry, no etymologies found.


  • Anderson noted that a concentrated ethereal solution of kamala after a few days formed a solid crystalline mass, yellow, very soluble in ether; this substance he named _rottlerin_, C_11_H_10_O_3_.

    The Medicinal Plants of the Philippines

  • After stimulation with Wnt5a (1 μg/ml, 30 minutes, 1 hour, 2 hours), Gö 6976 (100 nM, 30 minutes), and/or rottlerin (1 μM), EPC was lysed with lysis buffer (Cell Signaling) containing

    PLoS ONE Alerts: New Articles

  • Wnt5a (1 μg/ml) or PKC delta inhibitor, rottlerin (1 μM) were used. * indicates p doi: 10.1371/journal. pone.0005765.g003

    PLoS ONE Alerts: New Articles

  • Importantly, increased cardiac marker gene expression by Wnt5a was also inhibited by rottlerin, suggesting that PKC delta is an important mediator for cardiac gene expression via non-canonical Wnt signaling.

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  • For the inhibitory assay, rottlerin (1 μM, Calbiochem), PKC epsilon translocation inhibitor peptide and its control peptide (both 25 μM, Calbiochem), or Gö6976

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  • The PKC delta inhibitor rottlerin significantly blocked co-culture-induced cardiac differentiation in vitro, whereas inhibitors directed against the classical Ca

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  • Incubation with the relatively selective PKC delta inhibitor, rottlerin (1 μM), significantly attenuated cardiac differentiation (

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