Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun organic chemistry A poisonous
alkaloid found in theSouth American plant Ryania speciosa, originally used as aninsecticide .
Etymologies
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Examples
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Dr. Andrew Marks has been targeting something called the "ryanodine receptor" in muscle cells.
FOXNews.com 2011
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The third study, which appears online today in PLoS - Biology, describes in detail the molecular target of the PCBs, the calcium channels known as ryanodine receptors, and shows that PCBs lock these calcium channels in the open position, which likely contributes to the over-excitations of neural circuits observed in the two other studies.
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The investigators called the drugs rycals, because they attach to the ryanodine receptor/calcium release channel in heart muscle cells.
Finding May Solve Riddle of Fatigue in Muscles « Isegoria 2008
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Gubareff and I had shown that the decrease in force with ryanodine (unlike that with acetylcholine or adenosine) was not associated with a decrease in duration of the action potential.
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We also continued work with ryanodine, which produced a negative inotropic effect on the guinea-pig atrium and actually changed the force-frequency effect from a positive to negative staircase
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The thesis research of Grossman and a few years later that of another graduate student, Peter Wolf, also using 45Ca to measure effects of ryanodine on calcium exchange, led to a hypothetical model that fits fairly well with more recent work of others on the reactions of ryanodine with "receptors" involved with calcium transport in the sarcoplasmic reticulum.
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Lead author Dr. Andrew Marks, director of the Wu Center for Molecular Cardiology at Columbia University Medical Center, said in a news release that sarcopenia and muscular dystrophy may have ryanodine receptor leakage in common.
The Seattle Times 2011
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The online study, released Tuesday in the journal Cell Metabolism, maintains that sarcopenia happens because of calcium seepage from the ryanodine receptor channel complex, a group of proteins found in muscle cells.
The Seattle Times 2011
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When the brain sends a signal to the muscle to contract, the ryanodine receptor acts like a fuel pump and releases calcium into the cell, where it's used to pull muscle fibers together.
FOXNews.com 2011
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E, et al. (2005) Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.
PLoS Biology: New Articles Ting-Ting Hong et al. 2010
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