Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun An
oral nucleoside analogue prodrug with potential uses inchemotherapy .
Etymologies
Sorry, no etymologies found.
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Examples
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Seliciclib (CYC202 or R-roscovitine), a CDK (cyclin dependent kinase) inhibitor, is in Phase 2 studies for the treatment of lung cancer and nasopharyngeal cancer and in a Phase 1 trial in combination with sapacitabine.
unknown title 2011
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In the multicenter, Phase 1/2 clinical trial examining the safety and effectiveness of oral sapacitabine administered sequentially with decitabine, 30-day mortality from all causes was 4.5% and 60-day mortality from all causes was 9.5%.
unknown title 2011
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Previous findings show that cells with defects in this chromosome region, such as inactivation of ATM, are particularly sensitive to sapacitabine Liu, X, et al
unknown title 2011
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Both sapacitabine and CNDAC, its major metabolite, have demonstrated potent anti-tumor activity in preclinical studies.
unknown title 2011
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The objective of the study is to learn if oral sapacitabine capsules given in combination with two standard injectable drugs, cyclophosphamide and rituximab, or the "SCR regimen", can help control chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) in up to 40 relapsed patients with leukemia cells containing the 11q22-23 chromosome deletion.
unknown title 2011
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Previous findings show that cells with HRR pathway defects are particularly sensitive to sapacitabine.
unknown title 2011
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"As gene-based, personalized medicine approaches have in certain cases been developed and approved faster than traditional methods, we are encouraged by the prospect of tailoring treatment with sapacitabine to the genetic profile of an individual's cancer cells," said Spiro Rombotis, President and CEO of Cyclacel.
unknown title 2011
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The trial is being funded by MD Anderson's Leukemia Department with Cyclacel contributing sapacitabine and a small grant to support the performance of certain exploratory diagnostic tests.
unknown title 2011
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Seliciclib (CYC202 or R-roscovitine), a CDK (cyclin dependent kinase) inhibitor, is in Phase 2 studies for the treatment of lung cancer and nasopharyngeal cancer and in a Phase 1 trial in combination with sapacitabine.
unknown title 2011
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Over 300 patients have received sapacitabine in Phase 2 studies in AML, MDS, cutaneous T cell lymphoma CTCL and NSCLC.
unknown title 2011
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