Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective anatomy Of or pertaining to
sarcomeres .
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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Before duplication the ancestral sarcomeric α-actinin had the functions of both ACTN2 and ACTN3 in terms of tissue expression and functional isoforms.
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Using sarcomeric α-actinin as an example, after duplication of a gene capable of multiple interactions/functions, there are two possible distinct scenarios besides gene loss.
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Lek M, Quinlan KG, North KN 2009 The evolution of skeletal muscle performance: gene duplication and divergence of human sarcomeric alpha-actinins.
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CM sarcomeric proteins can directly cause thin filament deactivation
PLoS ONE Alerts: New Articles Jennifer Davis et al. 2010
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Adding to the complexity of CM is the realization there are ~467 CM-linked mutant alleles that have been reported in eleven different sarcomeric genes
PLoS ONE Alerts: New Articles Jennifer Davis et al. 2010
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Integrin-mediated adhesion maintains sarcomeric integrity.
SpaceRef Top Stories 2010
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Collectively, these data demonstrate that within the context of the physiologically intact unloaded myocyte coexpressing a deactivating and an activating sarcomeric allele from different loci partially mitigates the primary effects elicited by each mutant alone.
PLoS ONE Alerts: New Articles Jennifer Davis et al. 2010
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Thus, our working hypothesis is that altered biophysical properties of double mutant sarcomeric proteins could interact to either heighten or mitigate the functional cellular outcomes of either mutant allele when studied in isolation.
PLoS ONE Alerts: New Articles Jennifer Davis et al. 2010
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While this activating activating/deactivating paradigm should be tested on other mutant sarcomeric alleles, support for our model can be derived from double heterozygous patients with a combined myosin and troponin mutation that have early morbidity and an increased incidence of surgical treatment and sudden cardiac death, as well as the increased mortality in the MyHC R403Q + G203S cTnI double heterozygous mice described above
PLoS ONE Alerts: New Articles Jennifer Davis et al. 2010
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This formula is calculated for total number of mutations within each sarcomeric loci and then summated to equal 33,737 possible genotypes.
PLoS ONE Alerts: New Articles Jennifer Davis et al. 2010
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