Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A drug being researched for the treatment of certain lung cancers and other disorders.
Etymologies
Sorry, no etymologies found.
Examples
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Patient biomarker analysis from the APPRAISE Phase 2b randomized discontinuation study of seliciclib in patients with NSCLC.
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Continued collection of patient specimens from the APPRAISE randomized, double-blinded, randomized discontinuation, Phase 2b study of seliciclib in patients with NSCLC who failed at least two prior therapies.
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The new information was potentially exciting for seliciclib because lung cancer with KRAS mutations has proven to be resistant to treatment with currently approved drugs like Tarceva and Erbitux.
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However With seliciclib news supposedly out this month or any time before the end of year it makes me question the results in seliciclib.
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Fast forward to January, when a research paper was published showing that seliciclib was highly effective at killing non-small cell lung cancer cells with a mutated copy of a gene known as KRAS.
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In August 2008, an independent data safety monitoring committee concluded that seliciclib wasn't likely to demonstrate an improvement in progression-free survival because there was no efficacy trend in favor of seliciclib-treated patients compared to patients treated with best supportive care at that time.
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I think it's a good idea to keep expectations tempered for seliciclib, Cylcacel's experimental lung cancer drug.
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The study was allowed to continue, however, because seliciclib was safe and there wasn't enough data to reach a definitive conclusion about the study's outcome.
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The new research suggested a way by which seliciclib might serve an unmet medical need benefiting patients with KRAS-mutated lung cancer.
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CYCC said topline results from a mid-stage clinical study showed oral seliciclib as a third or more line treatment in patients with non-small cell lung cancer did no better than a placebo in terms of progression free survival.
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