from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A drug designed to treat Alzheimer's disease but never marketed.


Sorry, no etymologies found.


  • Eli Lilly and Co last year halted two studies of its gamma-secretase drug, called semagacestat, after it worsened patients' symptoms of dementia in late-stage clinical trials.

    Reuters: Top News

  • That go-ahead suggested the drug so far has sidestepped the kinds of safety issues that doomed the earlier Lilly medicine called semagacestat in 2010.

    Reuters: Press Release

  • The experimental medicine, called semagacestat, didn't slow the disease's progression in two studies.

    SFGate: Top News Stories

  • The company said the drug, called semagacestat, did not slow progression of the disease and was associated with a worsening of cognition and the ability to perform the tasks of daily living. :

  • The drug candidate, LY450139, which is also known as semagacestat, is being studied in clinical trials by Eli Lilly and Company.

    Science Blog - Science news straight from the source

  • It halted study of a promising Alzheimer's drug, called semagacestat, because the compound worsened patients 'conditions in two clinical trials.

    U.S. Delays Approval of Diabetes Treatment

  • Last year, Lilly halted development of its gamma secretase inhibitor, semagacestat, after two phase III studies showed it didn't slow down the disease and was linked to worsening of cognitive symptoms.

    Alzheimer's Treatment Showcase Is Set

  • Lilly's semagacestat aimed to slow or reverse the progression of Alzheimer's disease by inhibiting an enzyme called gamma secretase, which is important in building a sticky substance called amyloid that can clump in the brain.

    Failed Lilly Drug Prompts Concern

  • The compound, semagacestat, is no longer in development, but with similar drugs from Bristol-Myers Squibb Co. and EnVivo Pharmaceuticals also in the works, the new findings presented at the Alzheimer's Association International Conference here are being closely watched.

    Failed Lilly Drug Prompts Concern

  • Other gamma secretase compounds in development may not exhibit the same effect because they are more selective than semagacestat, thus avoiding interaction with other proteins known to cause problems if blocked, while others work by modulating or changing the effect of gamma secretase on amyloid rather than blocking its effect as inhibitors do.

    Failed Lilly Drug Prompts Concern


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