Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any of a class of proteins that assist growing axons to find an appropriate target and to form synapses

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

From semaphore + -in

Examples

  • The researchers identified a single-letter change on chromosome 5 near a gene called semaphorin 5A, which is believed to help guide the growth of neurons and their long progressions, called axons.

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  • Similar to the cadherins identified in the first study, semaphorin 5A is thought to play an important role in neural development.

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  • Recently, highly unusual proteins of the Mical family of enzymes have been found to associate with the cytoplasmic portion of plexins, which are large cell-surface semaphorin receptors, and to mediate axon guidance, synaptogenesis, dendritic pruning and other cell morphological changes

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  • We found that Mical is both necessary and sufficient for semaphorin-plexin-mediated F-actin reorganization in vivo.

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  • Using two lines of mice - one missing semaphorin and another missing neuropilin, its receptor - postdoctoral fellow Tracy Tran used a classic staining method called the Golgi technique to look at the anatomy of nerve cells from mouse brains.

    Biosingularity

  • The spines of both semaphorin-lacking and neuropilin-lacking mice were dramatically enlarged, compared to those of the smaller, spherical-looking spines in the wild-type mice.

    Biosingularity

  • Tran saw unusually pronounced "spines" sprouting willy-nilly in peculiar places and in greater numbers on the dendrites in the neurons of semaphorin-lacking and neuropilin-lacking mice compared to the normal wild-type animals.

    Biosingularity

  • Kolodkin, a professor in the neuroscience department at Johns Hopkins and a Howard Hughes Medical Institute investigator, discovered and cloned the first semaphorin gene in the grasshopper when he was a postdoctoral fellow.

    Biosingularity

  • Nature, reveal that semaphorin, a protein found in the developing nervous system that guides filament-like processes, called axons, from nerve cells to their appropriate targets during embryonic life, apparently assumes an entirely different role later on, once axons reach their targets.

    Biosingularity

  • Miao HQ, Soker S, Feiner L, Alonso JL, Raper JA, et al. (1999) Neuropilin-1 mediates collapsin-1 / semaphorin III inhibition of endothelial cell motility: functional competition of collapsin-1 and vascular endothelial growth factor-165.

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