Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Plural form of semaphorin.
Etymologies
Sorry, no etymologies found.
Examples
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Here we report that Mical directly links semaphorins and their plexin receptors to the precise control of actin filament (F-actin) dynamics.
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Mical therefore is a novel F-actin-disassembly factor that provides a molecular conduit through which actin reorganization-a hallmark of cell morphological changes including axon navigation-can be precisely achieved spatiotemporally in response to semaphorins. can view articles published from 1997 to the current issue.
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Alex Kolodkin, Ph. D., showed that semaphorins affect axon trajectory and growth, they suspected that perhaps these guidance molecules might have some involvement with dendrites.
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In postnatal development and adulthood, semaphorins appear to be regulating the creation of synapses - those connections that chemically link nerve cells.
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"With this discovery we're able to understand how semaphorins regulate the number of synapses and their distribution in the part of the brain involved in conscious thought," says
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There is actually considerable overlap between the axon guidance and ephrin signaling pathways with ephrins along with netrins, slits and semaphorins being the main families of guidance molecules in the developing nervous system
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These disparate effects of secreted semaphorins are reflected in the restricted dendritic localization of Npn-2 to apical dendrites and of Npn-1 (also known as Nrp1) to all dendrites of cortical pyramidal neurons.
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This included the upregulated neuropilin (NRP1) and plexin-A4 (PLXNA4), which together comprise the receptor for semaphorins
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