Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. The monoaldehyde of a dicarboxylic acid; those of some amino acids are intermediates in biosynthesis

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

semi- +‎ aldehyde

Examples

  • The region includes genes encoding a CoA-dependent methylmalonate semialdehyde dehydrogenase (dntE), a putative NADH-dependent dehydrogenase (ORF13), and a bifunctional isomerase/hydrolase (dntG).

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  • * 'By the addition of hydrogen and ammonia to carbon suboxide, malonamide semialdehyde or malonamide semialdimine might be obtained.

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  • Chambliss K, Hinson DD, Trettel F, Malaspina P, Novelletto A, et al. (1998) Two exon-skipping mutations as the molecular basis of succinic semialdehyde dehydrogenase deficiency (4-hydroxybutyric adicuria).

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  • Hoffmann GF, Hodson AK, Bottiglieri T, Jakobs C (1998) 4-Hydroxybutyric acid and the clinical phenotype of succinic semialdehyde dehydrogenase deficiency, and inborn error of GABA metabolism.

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  • In mammals succinic semialdehyde dehydrogenase (SSADH) plays an essential role in the metabolism of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) to succinic acid

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  • Akaboshi S, Hogema BM, Novelletto A, Malaspina P, Salomons GS, et al. (2003) Mutational spectrum of the succinic semialdehyde dehydrogenase (ALDH5A1) gene and functional analysis of 27 novel disease-causing mutations in patients with SSADH deficiency.

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  • Gupta M, Senephansiri H, Burlingame TG, Taylor M, et al. (2001) Pharmacologic rescue of lethal seizures in mice deficient in succinic semialdehyde dehdrogenase.

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  • Australia In mammals succinic semialdehyde dehydrogenase (SSADH) plays an essential role in the metabolism of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) to succinic acid

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  • Yoo BK, Lee SJ, Cho SW, et al. (1995) Bovine brain succinic semialdehyde dehydrogenase; purification, kinetics and reactivity of lysyl residues connected with catalytic activity.

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  • Boyl PP, Ledda M, Novelletto A, Gibson KM, et al. (2002) Structure of human succinic semialdehyde dehydrogenase gene: identification of promoter region and alternatively processed isoforms.

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