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Examples
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A protein called separase is the target of a proposed therapy to attack breast cancer, according to Debananda Pati of the Texas Children's Hospital Cancer Center and Yizhi Jane Tao, an assistant professor of biochemistry and cell biology at Rice.
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A crucial aspect of this process is sister chromatid separation, which is thought to be mediated by separase, a thiol protease activated by the APC./C. Separase cleaves cohesin, a ring-shaped complex that entraps sister DNAs.
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A crucial aspect of this process is sister chromatid separation, which is thought to be mediated by separase, a thiol protease activated by the APC./C. Separase cleaves cohesin, a ring-shaped complex that entraps sister DNAs.
Naturejobs - All Jobs Raquel A. Oliveira 2010
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Having discovered in a previous study that separase is significantly over-expressed in more than 60 percent of human breast tumors, the researchers plan to study the three-dimensional structure of separase and then design or identify small molecule inhibitors to stop tumors while leaving normal cells alone.
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In the MI stage, homologous chromosomes could form bivalents by chiasma, and separase-mediated cleavage of Rec8 did not occur until the onset of AI
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