Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. An atypical antipsychotic drug.

Etymologies

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Examples

  • Antiviral response which represents serpivite claims managers sertindole refore capable serzone attorneys.

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  • The panel voted 8-2 (three panelists abstained from the vote) in favor of FDA approval for Serdolect (sertindole) among certain patients (such as those who do not respond to other treatments) despite concerns about heart-related risks.

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  • Much more worrisome, sertindole was associated with a fivefold greater risk of sudden cardiac death than risperidone (hazard ratio 5.1, 95\% confidence interval 1. 5-17.9).

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  • Because there are safer approved therapies for schizophrenia, and because sertindole is not more effective than any of these other drugs, we believe that the risk of sudden cardiac death is unacceptable and this drug should not be approved.

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  • On April 7, 2009, the Psychopharmacologic Drugs Advisory Committee met to discuss the use of sertindole in schizophrenia.

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  • The Sertindole Cohort Prospective (SCoP) Study was conducted to measure the risk of sudden cardiac death in patients with schizophrenia by randomizing nearly 10,000 patients to either sertindole or risperidone.

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  • The increased risk of sudden cardiac death with sertindole presents a significant public health danger, and it is hard to justify tolerating this risk when this drug is no more effective than other approved therapies for schizophrenia.

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  • Although sertindole had not been approved by the FDA, marketing in Europe was approved in

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  • The pre-specified primary endpoint of all-cause mortality was not significantly different with these two drugs, but the study failed to exclude a 50\% increase in mortality with sertindole using conventional 95\% confidence intervals.

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  • Because of evidence from a large randomized controlled trial of an increase in risk of sudden cardiac death, the committee voted that sertindole is unsafe for broad use in schizophrenia.

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