Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun biochemistry Any of a group of membrane-bound enzymes that cleave extracellular portions of transmembrane proteins, releasing the soluble ectodomains from the cell surface.

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

shed +‎ -ase?

Examples

  • These programs include phase I trials for its HIV and diabetes INDs, filings of three to four more INDs by year's end, a potential milestone payment from Pfizer, and phase I and phase II trails of its sheddase inhibitor that treats tumors.

    Incyte Narrows Earnings Gap

  • "As such, we believe that Incyte shares will trade sideways until proof-of-concept data is presented from Incyte's other R&D programs including the sheddase inhibitor and diabetes programs."

    Incyte Plagued With Uncertainty

  • Turning now to our sheddase inhibitor, Incyte 7839, which is under development for breast cancer, results from the ongoing Phase 2 trial continue to demonstrate that the combination of

    Incyte CEO Discusses Q3 2010 Results - Earnings Call Transcript -- Seeking Alpha

  • I just wanted to maybe ask a couple questions about the sheddase program.

    Incyte CEO Discusses Q3 2010 Results - Earnings Call Transcript -- Seeking Alpha

  • When we started the study, adding the sheddase inhibitor to Herceptin and then to Herceptin plus chemotherapy - and what we were finding was that people who were both HER2-positive and

    Incyte CEO Discusses Q3 2010 Results - Earnings Call Transcript -- Seeking Alpha

  • Lebel A, McMahon S, Fournier I, Fugere M, et al. (2003) TACE/ADAM-17 maturation and activation of sheddase activity require proprotein convertase activity.

    PLoS ONE Alerts: New Articles

  • Cytori: RESTORE 2 data show high level of patient and physician satisfaction Cytori reports results supporting efficacy of cell-enriched fat grafting Incyte announces positive results for selective oral sheddase inhibitor study Is Sunesis The Next 10-Bagger?

    BloggingStocks

  • - (Business Wire) Incyte Corporation (Nasdaq: INCY) announced today positive results from an ongoing Phase I/II clinical trial for its selective oral sheddase inhibitor, INCB7839, involving 46 patients with HER2 positive metastatic breast cancer.

    The Earth Times Online Newspaper

  • For example, fusing the integrin ectodomain to vasorin's transmembrane and cytoplasmic domains precludes both sheddase and γ-secretase cleavage.

    PLoS Biology: New Articles

  • Chief Medical Officer and Director of Drug Development, Sarah Cannon Research Institute (SCRI), Nashville, Tennessee, stated, "The results of this proof of concept study, while limited to a small number of patients, are encouraging and suggest that the combination of the sheddase inhibitor with trastuzumab may offer a new therapeutic approach in HER2 positive breast cancer.

    The Earth Times Online Newspaper

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