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The survival of a pathogen within the host in rather unfavorable conditions depends on its ability to manipulate its structural proteins and the regulatory components such as the proteins of the bacterial signal-transduction pathway which ensure that the structural factors are spatially and temporally regulated.
This binding inhibits the activation of the receptor and the subsequent signal-transduction pathway, which results in reducing both the invasion of normal tissues by tumor cells and the spread of tumors to new sites.
The metastatic process involves the coordination of several cellular and signal-transduction pathways that allow cancer cells to proliferate, remodel their surrounding environment, invade to distant site and form new tumors.
This binding inhibits the activation of the receptor and the subsequent signal-transduction pathway, which results in reducing both the invasion of normal tissues by tumour cells and the spread of tumours to new sites.
Macromolecular traffic between the nucleus and the cytoplasm is enabled by nuclear pore complexes (NPCs), large macromolecular assemblies that punctuate the nuclear envelope (NE): transport across the NPC not only localizes proteins destined to the nucleus or cytoplasm, but also plays a key role in signal-transduction pathways and in the regulation of major cellular processes (for review see