Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry Any of a group of
proteins , complexes of which are involved in theregulation ofprotein degradation
Etymologies
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Examples
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Of particular importance is the realization that either: the "tool kit" for development includes the COP9 signalosome and other ubiquitin/SUMO-related systems; or 2. many members of the "tool kit" are the direct targets of the COP9 signalosome.
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Furthermore, the concept of a signalosome involving disease-associated factors, such as DISC1 and glutamate, may well contribute to the multifactorial and polygenetic characteristics of schizophrenia.
Naturejobs - All Jobs Akiko Hayashi-Takagi 2010
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Figure 5: Regulation of Rac1 activity via signalosome of DISC1-Kal-7.
Naturejobs - All Jobs Akiko Hayashi-Takagi 2010
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With special emphasis we characterize the biochemical functions of the multiprotein complex COP9 signalosome and its importance in the regulation of NF-kappaB.
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With special emphasis we characterize the biochemical functions of the multiprotein complex COP9 signalosome and its importance in the regulation of NF-kappaB.
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With special emphasis we characterize the biochemical functions of the multiprotein complex COP9 signalosome and its importance in the regulation of NF-kappaB.
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Kovalenko A, Cantarella G, Wallach D (2000) Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation.
PLoS ONE Alerts: New Articles Ping Liu et al. 2009
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Another possibility is that HBD plays a role in creating the tolerizing phenotype, but only as a part of TSP-1, when a signalosome is formed
PLoS ONE Alerts: New Articles Adi Tabib et al. 2009
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