from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any of a group of proteins, complexes of which are involved in the regulation of protein degradation


Sorry, no etymologies found.


  • Of particular importance is the realization that either: the "tool kit" for development includes the COP9 signalosome and other ubiquitin/SUMO-related systems; or 2. many members of the "tool kit" are the direct targets of the COP9 signalosome.

    Carroll and the ancient genetic tool kit

  • Furthermore, the concept of a signalosome involving disease-associated factors, such as DISC1 and glutamate, may well contribute to the multifactorial and polygenetic characteristics of schizophrenia.

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  • Figure 5: Regulation of Rac1 activity via signalosome of DISC1-Kal-7.

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  • With special emphasis we characterize the biochemical functions of the multiprotein complex COP9 signalosome and its importance in the regulation of NF-kappaB.

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  • Kovalenko A, Cantarella G, Wallach D (2000) Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation.

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  • Another possibility is that HBD plays a role in creating the tolerizing phenotype, but only as a part of TSP-1, when a signalosome is formed

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