from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Any of a group of proteins, complexes of which are involved in the regulation of protein degradation
Sorry, no etymologies found.
Of particular importance is the realization that either: the "tool kit" for development includes the COP9 signalosome and other ubiquitin/SUMO-related systems; or 2. many members of the "tool kit" are the direct targets of the COP9 signalosome.
Furthermore, the concept of a signalosome involving disease-associated factors, such as DISC1 and glutamate, may well contribute to the multifactorial and polygenetic characteristics of schizophrenia.
Figure 5: Regulation of Rac1 activity via signalosome of DISC1-Kal-7.
With special emphasis we characterize the biochemical functions of the multiprotein complex COP9 signalosome and its importance in the regulation of NF-kappaB.
Kovalenko A, Cantarella G, Wallach D (2000) Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation.
Another possibility is that HBD plays a role in creating the tolerizing phenotype, but only as a part of TSP-1, when a signalosome is formed