single-molecule love



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  • The single-molecule sequencing method the HeliScope is based on has proved extremely difficult to build into a machine at a competitive price.

    The $1,000 Genome

  • Moreover, it was the first report of decoding a human genome by single-molecule sequencing and a timely shot in the arm for embattled Helicos.

    The $1,000 Genome

  • “Electrical, single-molecule sensing on an instrument the size of a laptop is going to transform a lot of areas, not just DNA sequencing.”

    The $1,000 Genome

  • Balasubramanian said he could have submitted the same story five years earlier: “Steve Quake was the first to publish and will say he invented single-molecule sequencing, but we had the first patent on it.”

    The $1,000 Genome

  • In fact, Bayley stayed away from DNA sequencing as a professional courtesy to Branton, making progress in chemically modifying the hemolysin to use it as a single-molecule sensor for drugs, chemicals, and metal ions.

    The $1,000 Genome

  • Michael J. Levene et al., “Zero-mode waveguides for single-molecule analysis at high concentrations,” Science 299 2003, 682–686.

    The $1,000 Genome

  • Using genetic sequences from 33,996 Americans, Canadians and Europeans, researchers in the present study identified three sections of DNA where a single-molecule mutation increased or decreased the risk for vitamin D deficiency.

    The Long and Short of Heart-Disease Risk

  • Pleasure time may not be what you want to devote to reading Chu's latest article in the journal Nature: "Subnanometre single-molecule localization, registration and distance measurements."

    A man's gotta have a hobby: Energy Secretary Steven Chu publishes scientific research in his spare time.

  • In spring 2003, another competitor emerged 6,000 miles away when Steve Quake and colleagues at Caltech published a paper on a method for single-molecule DNA sequencing that was similar in some ways to what Solexa had been developing, only the Brits had chosen not to publish.

    The $1,000 Genome

  • Brown remembered Swerdlow listing all the cumulative inefficiencies of single-molecule sequencing on a whiteboard.

    The $1,000 Genome


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