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Examples

  • Amore G, Yavrouian RG, Peterson KJ, Ransick A, McClay DR, et al. (2003) Spdeadringer, a sea urchin embryo gene required separately in skeletogenic and oral ectoderm gene regulatory networks.

    PLoS Biology: New Articles 2009

  • Furthermore, the network response to ActivinB signaling reveals greater complexity in an additional uncharacterized inductive signal emitted by skeletogenic precursors.

    PLoS Biology: New Articles 2009

  • To investigate these networks, we ectopically activated a GRN that operates in skeletogenic precursors and characterized the responding GRN in neighboring cells, which adopt an endomesoderm fate.

    PLoS Biology: New Articles 2009

  • By testing the responsiveness of every core factor in the responding GRN, which allowed us to identify a subset that executes the response to the induction, we demonstrated that the signaling molecule, ActivinB, is an essential component of this induction and that its function is physiologically relevant: it is required during normal embryonic development to activate the same GRN that responds to signals from skeletogenic precursors.

    PLoS Biology: New Articles 2009

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