from The American Heritage® Dictionary of the English Language, 4th Edition
- n. Any of a group of peptides produced by the liver upon stimulation by somatotropin that act directly on cartilage cells to stimulate skeletal growth.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Any of a group of peptides which mediate the action of somatotropin on cartilage
Insulin-like growth factor also called somatomedin is a protein hormone similar in structure and function to insulin, but with much higher growth-promoting activity than insulin.
For example, somatomedin or insulin-like growth factor, which mediates the growth-promoting effect of growth hormone, was isolated from human plasma.
This work led to my appreciation of the role of specific serum factors in the control of cell multiplication and the demonstration that a multiplication-stimulating factor in calf serum for chicken fibroblasts was the same as somatomedin.
For example pituitary gland, helps to stimulate growth through the release of somatomedin.
For example, pituitary gland, helps to stimulate growth through the release of somatomedin.
Growth hormone stimulates the release of the hormone somatomedin by the liver, causing growth.
The interactions between the two proteins have been attributed primarily to binding of the somatomedin B (SMB) domain, which comprises the N-terminal 44 residues of vitronectin, to the flexible joint region of PAI-1, including residues Arg-103,