from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A polypeptide hormone produced chiefly by the hypothalamus that inhibits the secretion of various other hormones, such as somatotropin, glucagon, insulin, thyrotropin, and gastrin.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry A
polypeptide hormone, secreted by the pancreas, that inhibitsthe production of certain other hormones.
from The American Heritage® Dictionary of the English Language, 4th Edition
from Wiktionary, Creative Commons Attribution/Share-Alike License
It is now commonly accepted that there are a group of peptides such as somatostatin (49, 50), substance P (51), vasoactive intestinal peptide (52) and cholecystokinin or its C-terminal octapeptide
Nor do the authors have good words for dairy which they write treats unwitting consumers to prolactin, somatostatin, melatonin, oxytocin, growth hormone, luteinizing hormone-releasing hormone, thyrotropin-releasing hormone, thyroid-stimulating hormone and fourteen other unwanted hormones in addition to fat, calories, cholesterol and antibiotics.
But then there was a seminar describing the synthesis and cloning of a gene for somatostatin.
My group synthesized several new classes of antitumor peptides such as LH-RH antagonists, somatostatin analogs, bombesin/GRP antagonists, GH-RH antagonists and targeted cytotoxic analogs of LH-RH, bombesin and somatostatin.
My group demonstrated that the receptors for LH-RH, somatostatin and bombesin are present in various tumors, including human prostatic, mammary, endometrial and ovarian cancers.
Professor S. Konturek showed that somatostatin also inhibits gastric acid and pepsin secretion, and the release of duodenal hormones, secretin and cholecystokinin.
The clinical work on somatostatin was carried out mainly in England.
Based on this demonstration of receptors for peptides in various tumors, I started in 1995 the development of modern cytotoxic analogs of LH-RH, bombesin and somatostatin, which can be targeted to peptide receptors on various primary cancers and their metastases.
Particularly important was the establishment of a radioimmunoassay for somatostatin by Dr. Arimura.
P. Brazeau and collaborators in 1973 announced the isolation and structure of ovine somatostatin, we purified this hormone from porcine hypothalami, determined its structure and synthesized it.