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sphingomyelinase

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun biochemistry Any of several enzymes that catalyzes the cleavage of phosphodiester bonds in sphingomyelin

Etymologies

Sorry, no etymologies found.

Examples

  • International Journal of Cancer, shows that the omega-3 fatty acids found in cold water fish-docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) - curb the growth of breast cancer cells via yet another protective mechanism: by activating an enzyme called sphingomyelinase, which then generates the release of ceramide, a compound that induces the expression of the human tumor suppressor gene p21, which ultimately causes cancer cell death.

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  • The study, published in the Journal of Neuroscience, determined neutral sphingomyelinase triggers neuronal death.

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  • "There are multiple, neurotoxic, disease-causing pathways that converge on the neutral sphingomyelinase that can cause neuronal loss in the brain of an Alzheimer's patient," lead investigator Kalipada Pahan says in a statement.

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  • Pena LA, Fuks Z, Kolesnick RN (2000) Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency.

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  • In the lab culture experiments, when cells were treated with DHA or EPA, these fats were incorporated into cell membranes with the result that sphingomyelinase activity increased by 30-40\%, and breast cancer cell growth dropped 20-25\%.

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  • Upregulation of acid sphingomyelinase (SMase) has been found in several inflammation-related diseases such as inflammatory bowel diseases, atherosclerosis, and diabetes.

    BioMed Central - Latest articles

  • Upregulation of acid sphingomyelinase (SMase) has been found in several inflammation-related diseases such as inflammatory bowel diseases, atherosclerosis, and diabetes.

    BioMed Central - Latest articles

  • Perrotta C, Bizzozero L, Falcone S, Rovere-Querini P, Prinetti A, et al. (2007) Nitric oxide boosts chemoimmunotherapy via inhibition of acid sphingomyelinase in a mouse model of melanoma.

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