from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. A nucleoprotein particle that aids in the splicing of messenger RNA in eukaryotes.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A dynamic complex of RNA and protein subunits that removes introns from precursor mRNA.


splice + -some3.
(American Heritage® Dictionary of the English Language, Fourth Edition)
splice +‎ -o- +‎ -some (Wiktionary)


  • Like a film director cutting out extraneous footage to create a blockbuster, the cellular machine called the spliceosome snips out unwanted stretches of genetic material and joins the remaining pieces to fashion a template for protein production. - latest science and technology news stories

  • By molecular-scale standards, the spliceosome is a monster of a machine, made up of five RNA and 100 or more protein subunits that agilely assemble, step-by-step, into the giant complex when it's time to carry out its work. - latest science and technology news stories

  • Scientists had also pinpointed how pladienolides kill cancer cells-by jamming a particular enzyme in the cancer cell's machinery, called a spliceosome, which enables the cell to edit its genetic blueprint molecule, RNA, in the replication process.


  • The spliceosome is a ribonucleoprotein machine that removes introns from pre-mRNA in a two-step reaction.

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  • This research, pursued with her husband Professor Joseph “Yossi” Sperling, culminated in 2004 with the publication of a detailed 3-D structure of the spliceosome “machine.”

    Ruth Sperling.

  • “Three-dimensional structure of the native spliceosome by cryo-electron microscopy.”

    Ruth Sperling.

  • For example, see the December 2003 BioEssays Special Issue on Molecular Machines, containing such articles as “The spliceosome: the most complex macromolecular machine in the cell?” and “Perpetuating the double helix: molecular machines at eukaryotic DNA replication origins.”

    The Edge of Evolution

  • Two important aspects of these processes are accurately managed by ribonucleoprotein machineries-the spliceosome and the ribosome.

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  • It is now known that spliceosome positions exon junction complexes (EJC) at 20-24 nt upstream of exon-exon junctions when introns are spliced out.

    PLoS ONE Alerts: New Articles

  • The large, highly overlapping complexes in the first row are mainly modules of the ribosome (6 out of 12) and spliceosome (3 out of 12).

    PLoS ONE Alerts: New Articles


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