Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A form of polymorphism in the repeat units of DNA

Etymologies

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Examples

  • Trends over time for lineages, spoligotype families and the commoner spoligotypes.

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  • Beijing strains had the identical, typical spoligotype.

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  • There was no evidence that the proportion of isolates that were isoniazid resistant varied by lineage, spoligotype or spoligotype family more than would be expected by chance.

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  • Assuming that other patients in the population with the same RFLP would have the same spoligotype, we inferred the spoligotype pattern for 100 of the RFLP-defined strains from the first cases in the pairs.

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  • The increase in Lineage 3 was due to an increase in the family CAS1-Kili, and most (44/49) of the CAS1-Kili strains were a single spoligotype (ST21).

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  • Isolates were grouped into spoligotype families and lineages following previously published criteria.

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  • This may be an artefact, as the spoligotype that we have designated ST59c, which differs from 59 only in the absence of spacer 15 was found only up to

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  • In order to define the lineage for the contact pairs we first linked the RFLP patterns to the spoligotype.

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  • Overall, spoligotype patterns were obtained from 760 smears from 518 different patients, some with multiple episodes of disease. 153 patients had multiple results from the same episode of disease, from smears taken within 3 months of each other (75 pairs, 40 triplets, 12 sets of four, one set of 5 and one of 6).

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  • Each spoligotype can have a range of RFLP fingerprints, so spoligotype clusters do not necessarily represent close epidemiological linkage, and increases in a particular spoligotype in a population are unlikely to result from single outbreak events.

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