Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun biochemistry Any of a group of proteins that are involved in axon guidance

Etymologies

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Examples

  • Tzarfaty-Majar V, Lopez-Alemany R, Feinstein Y, Gombau L, Goldshmidt O, et al. (2001) Plasmin-mediated release of the guidance molecule F-spondin from the extracellular matrix.

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  • Male C57Bl/6 mice received recombinant adenovirus expressing human R-spondin1 (AdRspo1) or E. coli Lacz (AdLacz), 1-3 days before whole body irradiation (WBI) or abdominal irradiation

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  • Male C57Bl/6 mice received recombinant adenovirus expressing human R-spondin1 (AdRspo1) or E. coli Lacz (AdLacz), 1-3 days before whole body irradiation (WBI) or abdominal irradiation

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  • Immunoblot analysis showed barely detectable levels of endogenous R-spondin1 in the serum of untreated mice.

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  • Nam JS, Turcotte TJ, Smith PF, Choi S, Yoon JK (2006) Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression.

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  • Semenov MV, Doble B, Woodgett J, et al. (2007) R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling.

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  • Recent reports indicate that the R-spondin proteins activate β-catenin signaling

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  • In order to examine the effect of R-spondin1 on tumor growth, AdRspo1 and AdLacZ was administered in the animals having palpable tumor and then exposed to AIR.

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  • The R-spondin (roof plate-specific spondin) family of proteins is comprised of novel secreted proteins, which acts as major agonists and modulators of the Wnt-β-catenin signaling pathway

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  • Because R-spondin1 (Rspo1) acts as a mitogenic factor for intestinal stem cells, we hypothesized that systemic administration of Rspo1 would amplify the intestinal crypt cells and accelerate the regeneration of the irradiated intestine, thereby, ameliorating RIGS.

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