from The American Heritage® Dictionary of the English Language, 4th Edition
- n. Any of the minute undeveloped sporozoans produced by multiple fission of a zygote or spore, especially at the stage just before it infects a new host cell.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Any of the minute active bodies into which a sporozoan divides just before it infects a new host cell.
from the GNU version of the Collaborative International Dictionary of English
- n. In certain Sporozoa, a small active, usually elongate, sickle-shaped or somewhat amœboid spore, esp. one of those produced by division of the passive spores into which the zygote divides. The sporozoites reproduce asexually.
from The Century Dictionary and Cyclopedia
- n. One of the minute germs of telosporidean Sporozoa, which enter the intestinal cells of vertebrates and start the life-cycle of the species to which they belong.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. one of the minute active bodies into which sporozoans divide in one stage of their life cycle
Plasmodium, for example, enters a human body through a mosquito bite as a zucchini-shaped form known as a sporozoite.
It has been known since the 1960s that one form of the malaria parasite - called the sporozoite - can wake up the immune system and help to protect against future infection.
Anti-sporozoite vaccines, designed to prevent infection.
Dr. Robert Sauerwein of the Radboud University Nijmegen Medical Centre, whose laboratory in collaboration with Sanaria has generated several genetically attenuated strains of Plasmodium falciparum concurs, stating, "This is a very exciting opportunity to make significant strides that will facilitate translation from the laboratory to clinical studies of a vialed, genetically attenuated, sporozoite vaccine inoculated by needle and syringe."
Sanaria's radiation attenuated sporozoite vaccine, Sanaria (TM) PfSPZ Vaccine, entered clinical trials in 2009.
According to Dr. Stephen L. Hoffman, Sanaria's founder and chief scientist, "Sanaria is uniquely positioned at this time to expand the pipeline of candidate sporozoite vaccines to include vaccines based on precisely gene-altered parasites that are highly potent in inducing protective immunity against malaria and are unable to cause disease."
Sanaria has developed technologies and built a facility to manufacture a radiation attenuated sporozoite vaccine that can be administered by injection and has met FDA regulatory standards for initial clinical evaluation.
"Sanaria's proven ability to manufacture whole sporozoite vaccines in compliance with FDA standards means that promising new strains of the malaria parasite that are being developed in our research laboratory can be efficiently translated into prototype candidate vaccines suitable for testing in the clinic," says Dr. David Fidock of Columbia University.
Sanaria has developed technologies and built a facility to manufacture a radiation attenuated sporozoite, is now being assessed in clinical trials.
According to Dr. Stephen L. Hoffman, Sanaria's founder and chief scientist, "Sanaria is uniquely positioned at this time to expand the pipeline of candidate sporozoite malaria and are unable to cause disease."