Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun medicine A
broad-spectrum antibiotic derived from thelivers ofdogfish
Etymologies
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Examples
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A complex compound produced by sharks, called squalamine, was discovered in 1993 but a new study is exploring its potential use against human viruses.
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Zasloff discovered the molecule, squalamine, in 1993 in the dogfish shark, a small- to medium-size shark found in the Atlantic, Pacific, and Indian Oceans.
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Yellow fever virus is often used as a surrogate lab test to show possible efficacy against hepatitis C, and the researchers were able to cure yellow fever in hamsters with squalamine.
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Zasloff holds several patents for the use of squalamine and related compounds for the treatment of
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The project began when lead investigator Michael Zasloff, professor of surgery and paediatrics at Georgetown University Medical Centre, sent samples of squalamine to a series of labs around the United States for testing.
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Researchers tested squalamine - manufactured from the liver of the dogfish shark - in lab dishes and in animal subjects and found it could inhibit or control viral infections, and in some cases appeared to cure animals of their ills.
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