Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry A brain-specific
transmembrane protein associated with a form ofepilepsy
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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However, the hypothesis that the D36 phenotypes might be due solely to dysregulation of AMPAR phosphorylation is an oversimplification, as there are numerous other PKA and calcineurin substrates near the PSD that can affect synaptic plasticity, including stargazin, NR1 subunits of the NMDAR, β-ARs, and L-type calcium channels
PLoS ONE Alerts: New Articles Michael Weisenhaus et al. 2010
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Park E, Lee JR, Yoon J, et al. (2002) Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95.
PLoS ONE Alerts: New Articles Michael Weisenhaus et al. 2010
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Ferron et al. now report that two proteins, stargazin-like γ7 protein and heterogeneous ribonuclear protein A2 (hnRNP A2, previously implicated in stabilizing, trafficking, and enhancing translation of specific mRNAs), interact to control expression of the voltage-dependent calcium channel Cav2. 2 by regulating its mRNA stability. hnRNP A2 binds to Cav2. 2 mRNA, increasing mRNA stability and protein expression. γ7 binds to hnRNP A2, disrupting its interaction with Cav2. 2 mRNA, which results in increased degradation of Cav2. 2 mRNA (and other mRNAs to which hnRNP A2 binds) and decreased protein expression.
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Ferron et al. now report that two proteins, stargazin-like γ7 protein and heterogeneous ribonuclear protein A2 (hnRNP A2, previously implicated in stabilizing, trafficking, and enhancing translation of specific mRNAs), interact to control expression of the voltage-dependent calcium channel Ca v2. 2 by regulating its mRNA stability. hnRNP A2 binds to Ca v2. 2 mRNA, increasing mRNA stability and protein expression. γ7 binds to hnRNP A2, disrupting its interaction with Ca v2. 2 mRNA, which results in increased degradation of Ca v2. 2 mRNA (and other mRNAs to which hnRNP A2 binds) and decreased protein expression.
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