Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun medicine An alkaloid derived from the bacterium Streptomyces staurosporeus that has antifungal and antihypertensive activity

Etymologies

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Examples

  • In 1976, a team of Japanese researchers looking for poisons in sea bacteria had accidentally discovered a molecule called staurosporine, a large molecule shaped like a lopsided Maltese cross that bound to a pocket present in most kinases.

    The Emperor of All Maladies Siddhartha Mukherjee 2010

  • In 1976, a team of Japanese researchers looking for poisons in sea bacteria had accidentally discovered a molecule called staurosporine, a large molecule shaped like a lopsided Maltese cross that bound to a pocket present in most kinases.

    The Emperor of All Maladies Siddhartha Mukherjee 2010

  • In 1976, a team of Japanese researchers looking for poisons in sea bacteria had accidentally discovered a molecule called staurosporine, a large molecule shaped like a lopsided Maltese cross that bound to a pocket present in most kinases.

    The Emperor of All Maladies Siddhartha Mukherjee 2010

  • Unlike staurosporine, though, this skeletal structure was a much simpler chemical.

    The Emperor of All Maladies Siddhartha Mukherjee 2010

  • Unlike staurosporine, though, this skeletal structure was a much simpler chemical.

    The Emperor of All Maladies Siddhartha Mukherjee 2010

  • Unlike staurosporine, though, this skeletal structure was a much simpler chemical.

    The Emperor of All Maladies Siddhartha Mukherjee 2010

  • RGC5 cells were transfected with pOPTN-EGFP for 20 h and underwent differentiation with treatment of 316 nM staurosporine for 4 h.

    PLoS ONE Alerts: New Articles Hongyu Ying et al. 2010

  • In some experiments, RGC5 cells were differentiated with 316 nM staurosporine for 4 h [39].

    PLoS ONE Alerts: New Articles Hongyu Ying et al. 2010

  • In this study, we found that jun N-terminal kinase (JNK) was activated in etoposide - and staurosporine-treated, but not serum-starved, Bax

    Naturejobs - All Jobs S Shimizu 2010

  • Nevertheless, they did stain positively for neuronal markers β-tubulin and PGP9. 5, as well as for the microtubule-associated protein, tau, and were able to differentiate with neurite extensions after treatment of staurosporine, suggesting that these cells still represent neuronal precursor cells.

    PLoS ONE Alerts: New Articles Hongyu Ying et al. 2010

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