I think you could say those two are strange bedfellows, because everyone would understand (I hope) that you are speaking of political bedfellows, and not actual, which, you know, would be okay as well, but even stranger.
I was. But now I come to think of it, can strange bedfellows simply exist, or do they have to be made? Is it legititmate to say of Pat and Rudy, "those two are strange bedfellows". Or do I have to call them an odd couple, while reiterating that politics makes strange bedfellows?