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streptozotocin

Definitions

from The American Heritage® Dictionary of the English Language, 5th Edition.

  • noun An antibiotic, C8H15N3O7, produced by an actinomycete (Streptomyces achromogenes), used primarily to treat pancreatic tumors affecting the Islets of Langerhans.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun A naturally-occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals, used to treat certain cancers.

Etymologies

from The American Heritage® Dictionary of the English Language, 4th Edition

[streptozōticus, epithet of the subspecies from which the antibiotic was isolated (strepto– + Greek zōtikos, maintaining life, pertaining to life; see gwei- in Indo-European roots) + –(my)cin.]

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Examples

  • The experimental diabetes model was induced in 8-week-old male Sprague-Dawley rats (250-300 g) by a single administration of streptozotocin.

    Naturejobs - All Jobs Jin-Hai Zhu 2010

  • They induced the disease by injecting them one time with a naturally occurring toxin, streptozotocin, which acts on cells in the pancreas.

    PhysOrg.com - latest science and technology news stories PhysOrg Team 2010

  • Hepatic dysfunction, becoming hands in allopurinol dog signs (ast and/or alt), streptozotocin bilirubin, and/or asymptomatic phosphatase, has elevated principally reported with augmentin.

    Wii-volution 2010

  • And after their endogenous islet cells are destroyed with the drugs streptozotocin the animals for weeks and weeks remain normal glycemic until they sacrifice to examine the graft.

    Geron CEO Discusses Q3 2010 Results - Earnings Call Transcript -- Seeking Alpha 2010

  • Using a transcriptomics approach, the aim of the study is to unravel the molecular mechanisms which participate in the recovery of exocrine and endocrine function of streptozotocin (STZ) diabetic rats treated with tungstate, determining the hyperglycemia contribution and the direct effect of tungstate.

    BioMed Central - Latest articles Jordi Altirriba 2009

  • Research at the University of Madras found that green tea extract ameliorates oxidative stress in the aorta and the heart of diabetic rats given streptozotocin (a chemical that is toxic to the insulin-producing cells of the pancreas).

    Business News and Business Products, Services, Reports and Advertising. Business News RSS Feed. 2009

  • Inhibition of RAS-GTPase signaling by chronic FPTIII treatment in streptozotocin-induced diabetic spontaneously hypertensive rats could ameliorate abnormal vascular responsiveness to endothelin-1, angiotensin II in isolated carotid artery.

    PLoS ONE Alerts: New Articles Hsin-Chou Yang et al. 2009

  • Recently, we identified Txnip (thioredoxin-interacting protein) as a mediator of glucotoxic beta cell death and discovered that lack of Txnip protects against streptozotocin - and obesity-induced diabetes by preventing beta cell apoptosis and preserving endogenous beta cell mass.

    Journal of Biological Chemistry current issue Cha-Molstad, H., Saxena, G., Chen, J., Shalev, A. 2009

  • A 21-day feeding study used rats that had received an intravenous injection of streptozotocin to induce diabetes.

    NutraIngredients-USA RSS 2008

  • Methodology/Principal Findings: VSMCs from autoimmune type 1 Diabetes Resistant Bio-Breeding (DR-BB) rats and streptozotocin-induced rats were examined for levels and distribution of inositol trisphosphate receptors (IP3R) and the SR Ca2+ pumps (SERCA 2 and

    BioMed Central - Latest articles Yvonne Searls 2010

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