Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun medicine A
non-steroidal anti-inflammatory drug used as ananalgesic andantipyretic
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun a nonsteroidal anti-inflammatory drug (trade name Clinoril)
Etymologies
Sorry, no etymologies found.
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Examples
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Research on how sulindac sulfide reduces risk of colorectal cancer published in Cancer Letters; student body president.
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Polyamines are associated with cell growth and cancer development, and previous research has shown that a polyamine-inhibiting regimen of difluoromethylornithine (DFMO) plus sulindac
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However, they found that DFMO/sulindac treatment only reduced adenoma risk among patients with lower intake of dietary polyamines, and not among those with higher dietary polyamine intake.
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In this randomized, phase III clinical trial researchers investigated the role of dietary intake of polyamines and the efficacy of DFMO/sulindac for preventing adenomas among 188 individuals.
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The results described provide further evidence that a combination of sulindac and an oxidizing agent might have clinical therapeutic value in treating a variety of cancers.
PLoS ONE Alerts: New Articles Maria Marchetti et al. 2009
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As noted above, sulindac is a pro-drug that must be converted to the active COX-inhibitor, sulindac sulfide
PLoS ONE Alerts: New Articles Maria Marchetti et al. 2009
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Ibuprofen, naproxen, indomethacin, and sulindac accounted for about 80\% of all NSAIDs used.
MedPageToday.com - medical news plus CME for physicians 2009
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Hooke K, Risley E, Shen T, Van Arman C (1977) Identification of the biologically active form of sulindac.
PLoS ONE Alerts: New Articles Maria Marchetti et al. 2009
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To determine whether the enhanced killing of sulindac-treated cancer cells by TBHP involved reduction of sulindac to sulindac sulfide, the active inhibitor of cyclooxygenases, the experiments described above were repeated using sulindac sulfone, which is not a substrate for MsrA (unpublished data) or a COX inhibitor
PLoS ONE Alerts: New Articles Maria Marchetti et al. 2009
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Thus, neither normal lung nor normal colon cells showed enhanced killing by TBHP following treatment with sulindac or sulindac sulfone, as was observed with the two cancer cell lines.
PLoS ONE Alerts: New Articles Maria Marchetti et al. 2009
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