Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun chemistry, biochemistry An
indolizidine alkaloid , found in various Swainsona and other species (includinglocoweed ), which disrupts the nervous system.
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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Arg149 makes a close contact to a swainsonine carbon (indicated with an arrow) of 2.9 Å (spatially equivalent to an H-bond to mannose O6 of the true substrate). doi: 10.1371/journal. pone.0009006.g004
PLoS ONE Alerts: New Articles Michael D. L. Suits et al. 2010
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Indeed, the anti-cancer indolizidine alkaloid, swainsonine, is a potent inhibitor of α − mannosidase II and has been shown to reduced metastasis and improved clinical outcomes when used in clinical trials for treatment of colon, breast, and skin cancers
PLoS ONE Alerts: New Articles Michael D. L. Suits et al. 2010
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Additionally, swainsonine is stabilized through stacking interactions of W18 with the five-membered ring, suggesting that the two aromatic residues contribute to positioning mannose into the correct orientation in the − 1 subsite.
PLoS ONE Alerts: New Articles Michael D. L. Suits et al. 2010
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(A) 3-D topology cartoon (divergent stereo) colored according to domains with swainsonine in ball-and-stick.
PLoS ONE Alerts: New Articles Michael D. L. Suits et al. 2010
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These active centre interactions with hydroxyl oxygens 1-3 of swainsonine correspond to analogous interactions between dGMII and hydroxyl groups at positions 4, 3, and 2 of α − mannose in the -1 subsite
PLoS ONE Alerts: New Articles Michael D. L. Suits et al. 2010
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Diffraction data for SpGH38 selenomethionine derivative, apo, and swainsonine complex forms were collected at beamlines ID29-2, ID14-2, and ID14-1, respectively, of the European Synchrotron Radiation Facility.
PLoS ONE Alerts: New Articles Michael D. L. Suits et al. 2010
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(D) schematic diagram of the interactions of swainsonine (shown in panel C) with H-bonds >
PLoS ONE Alerts: New Articles Michael D. L. Suits et al. 2010
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The natural product swainsonine is known to be a versatile glycosidase inhibitor having previously been used to study the active center of the.
PLoS ONE Alerts: New Articles Michael D. L. Suits et al. 2010
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S. pyogenes bound to the therapeutically important inhibitor swainsonine.
PLoS ONE Alerts: New Articles Michael D. L. Suits et al. 2010
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Subsequently, an inhibited form of SpGH38 in complex with swainsonine was determined at 2.6 Å resolution (discussed below).
PLoS ONE Alerts: New Articles Michael D. L. Suits et al. 2010
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