Definitions

from The American Heritage® Dictionary of the English Language, 4th Edition

  • adj. Genetically identical or closely related, so as to allow tissue transplant; immunologically compatible: syngeneic grafts; syngeneic animals.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • adj. genetically identical, or sufficiently identical and immunologically compatible as to allow for transplantation

Etymologies

From Greek sungeneia, kinship : syn-, syn- + genos, family; see genə- in Indo-European roots.
(American Heritage® Dictionary of the English Language, Fourth Edition)

Examples

  • Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic and semiallogeneic system.

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  • To investigate whether MSCs could provide a neuroprotective effect, we isolated and injected intravenously syngeneic MSCs into RCS rats at P30 (n = 12), at which time the retinal degeneration is at an early stage.

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  • Animals received syngeneic MSCs (1×106 cells) by tail vein at an age before major photoreceptor loss.

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  • To test whether pharmacological treatment of melanoma cells with IFN-γ and GGTI-298 could produce suitable cells for vaccination a murine model was used: B16F10 cell line, a poorly immunogenic and MHC-I negative melanoma of spontaneous origin, was injected in the syngeneic C57Bl/6 mice.

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  • Moreover, this treatment enables the T-cell-induced reduction of tumor growth in syngeneic immunocompetent mice and enhanced levels of B16F10 specific CD8 T lymphocytes TRP-2/H-2K

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  • Indeed, in vivo vaccination of syngeneic mice with pharmacologically pretreated melanoma cells induces tumor growth slowing down and reduction of pulmonary metastases implantation.

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  • Again syngeneic mice were vaccinated as previously described and challenged intra-venously with 5×10

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  • Vaccination of syngeneic mice with mIFN-γ+GGTI-298 pretreated B16F10 cells induces resistance to untreated tumor growth.

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  • EOMA cells are tumorigenic in syngeneic mice and exhibit characteristic endothelial cell properties.

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  • Pbγ-spz-immunized-challenged mice and from naïve-challenged mice and adoptively transferred into naïve syngeneic recipients (n = 13) that were challenged 7 days later with either 250 (n = 6) or 1000 (n = 7) infectious sporozoites.

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