Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun Plural form of
synthetase .
Etymologies
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Examples
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There is already chemical necessity between amino acids and their codons due to the aminoacyl-tRNA synthetases.
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There is already chemical necessity between amino acids and their codons due to the aminoacyl-tRNA synthetases.
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Since aminoacyl-tRNA synthetases are proteins, that necessity suffers from the chicken-and-egg problem when trying to explain the origin of translation.
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Aminoacyl-tRNA synthetases (aaRSs) are responsible for creating the pool of correctly charged aminoacyl-tRNAs that are necessary for the translation of genetic information (mRNA) by the ribosome.
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If so, what is the point of the remainder of the tRNA, its 3-D shape, its chemical make-up or the synthetases themselves?
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You are suggesting that small RNA would assume the function performed by protein amino acyl synthetases and if we presume all the foregoing what leads you to think this mixture would evolve to produce a cell?
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There is already chemical necessity between amino acids and their codons due to the aminoacyl-tRNA synthetases.
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Our framework fits naturally the recently proposed picture that early evolution was dominated by HGT, as evidenced by detailed phylogenetic (15), biochemical (16), and structural (17) analyses of the aminoacyl-tRNA synthetases.
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Yeah, a gradual, step by step development of DNA codons, mRNA, varieties of tRNA and amino acyl tRNA synthetases, and all that on route to a genetic code - now that's something to stick in your weed pipe.
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Genetic code origins: tRNAs older than their synthetases? is a PNAS paper which begins with this paragraph:
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