Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun pharmacy An
intravenous drug for thetreatment of renal cellcarcinoma , a derivative ofsirolimus .
Etymologies
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Examples
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"We look for a temsirolimus NDA before year-end, as efficacy in hard-to-treat renal cell carcinoma increases probability of approval," he said.
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"Interestingly, even if temsirolimus shows a significant efficacy advantage in this trial, there will be interest to try and benchmark these results versus those seen with Pfizer's Sutent and Bayer/Onyx Pharmaceuticals Nexavar, two recently approved drugs that will be direct competitors," the analyst noted.
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Patel said Wyeth's temsirolimus is a relatively risky drug candidate since it failed to show adequate efficacy previous clinical trials for breast and lung cancer.
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Specifically, the analyst discussed news of Bristol Myer Squibb's Sprycel; phase III studies in renal cell carcinoma for Pfizer's Sutent and Wyeth's temsirolimus and phase III data for refractory breast cancer for GlaxoSmithKline's Tykerb.
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The analyst said one other significant late-stage drug candidate is temsirolimus, a novel cancer treatment.
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Treatment with temsirolimus leads to cell cycle arrest in the G1 phase, and also inhibits tumour angiogenesis by reducing synthesis of VEGF.
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A phase 2 study of safety and efficacy of temsirolimus
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A phase 2 study of safety and efficacy of temsirolimus
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The RCC market has evolved into a rapidly growing segment since the launch of newer targeted therapies, such as: Pfizer's Sutent (sunitinib), Roche's Avastin (bevacizumab), Pfizer's Torizel (temsirolimus), and Bayer/Onyx 'Nexavar (sorafenib).
MMD Newswire: Press Release News Wire MMD Newswire 2010
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Treatment with temsirolimus leads to cell cycle arrest in the G1 phase, and also inhibits tumour angiogenesis by reducing synthesis of VEGF.
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