Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A podophyllotoxin derivative used in chemotherapy.

Etymologies

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Examples

  • Aneja R, Liu M, Yates C, Gao J, Dong X, et al. (2008) Multidrug resistance-associated protein-overexpressing teniposide-resistant human lymphomas undergo apoptosis by a tubulin-binding agent.

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  • Bugg BY, Danks MK, Beck WT, Suttle DP (1991) Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide.

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  • Desiderio, D.M.; Nemec, J.: Human cyto - chrome P450 metabolism of teniposide and etoposide.

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  • Podophyllotoxin and its derivatives are used in several commercially available pharmaceutical products such as the anticancer drugs etoposide, teniposide, and etopophos, which are used in the treatment of small-cell lung cancer, lymphoblastic leukemia, testicular cancer, and brain tumors.

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  • Furthermore, thaspine was found to have a reduced cytotoxic effect on the viability on CEM/VM-1, a cell line selected for resistance to the topoisomerase II inhibitor teniposide compared to the parental cell line CCRF-CEM (

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