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- n. A podophyllotoxin derivative used in chemotherapy.
Sorry, no etymologies found.
Aneja R, Liu M, Yates C, Gao J, Dong X, et al. (2008) Multidrug resistance-associated protein-overexpressing teniposide-resistant human lymphomas undergo apoptosis by a tubulin-binding agent.
Bugg BY, Danks MK, Beck WT, Suttle DP (1991) Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide.
Desiderio, D.M.; Nemec, J.: Human cyto - chrome P450 metabolism of teniposide and etoposide.
Podophyllotoxin and its derivatives are used in several commercially available pharmaceutical products such as the anticancer drugs etoposide, teniposide, and etopophos, which are used in the treatment of small-cell lung cancer, lymphoblastic leukemia, testicular cancer, and brain tumors.
Furthermore, thaspine was found to have a reduced cytotoxic effect on the viability on CEM/VM-1, a cell line selected for resistance to the topoisomerase II inhibitor teniposide compared to the parental cell line CCRF-CEM (