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Although thalidomide's terato - required only to show that the defendants bene - genicity affected only fetuses exposed during gesta - ﬁ ted from a substantial share of the drug market, tion - the second generation - increasing evidence to shift the burden to the defendants to show that showed that DES could cause injury to third-gen - they did not produce the particular injuring eration plaintiffs, the grandchildren of the woman drug; 14 and (d) Hymowitz theory, where the who originally ingested the drug.
These cover the principal aspects of reproductive biology, namely concep - Carcinogenicity studies involve the treatment of tion and implantation, organ formation and terato - rodents for long periods approximating to the com - genesis and ﬁ nally the development of offspring of plete life span (18 months to 2 years) to determine exposed maternal animals allowed to proceed to whether the test material possesses the capability to term. initiate or promote the development of tumors.