Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any protein-based tether that causes retention of virions on infected cell surfaces

Etymologies

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Examples

  • The name tetherin was coined 2 years ago, when BST-2 (also known

    Medlogs - Recent stories

  • Researchers have shown how an antiviral protein produced by the immune system, dubbed tetherin, tames HIV and other viruses by literally putting them on a leash, to prevent their escape from infected cells.

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  • Researchers have shown how an antiviral protein produced by the immune system, dubbed tetherin, tames

    Health News from Medical News Today

  • "tetherin" in the human immunodeficiency virus (HIV) research community, prevents progeny virus particles (virions) from escaping from the surface of the infected cell through a direct mechanism that requires only the protein's general structural features.

    New England Journal of Medicine

  • The tetherin sequence does vary quite a lot from one species to the next, he added, as is often the case due to strong selection when host defense genes meet viral inhibitors.

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  • The finding helped to confirm that tetherin is capable of acting all on its own, he added.

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  • The insights reported in the October 30th issue of the journal Cell, a Cell Press publication, allowed the research team to design a completely artificial protein -- one that did not resemble native tetherin in its sequence at all -- that could nonetheless put a similar stop to the virus.

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  • That's conceptually important, he continued, because there is no specific interaction between tetherin and any viral protein, which makes it a more difficult problem for viruses to evolve resistance.

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  • Bieniasz said there is some possibility that tetherin exists in different forms that might explain differences among people in the progression of HIV or other viral infections.

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  • In the case of HIV, a protein called Vpu counteracts tetherin.

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