Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A tetraspan.

Etymologies

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Examples

  • Overexpressing CD82 or CD9, members of the tetraspanin family of transmembrane proteins, suppressed Wnt signaling and reduced beta-catenin protein levels.

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  • The tetraspanin CD151 is highly abundant in the basolateral surface of basal keratinocytes

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  • The number of virions that were found to be associated with tetraspanin microdomains on the cell surface increased, as the infection process progressed.

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  • Altogether, these results supported the notion that HPV16 associates with tetraspanin proteins on the plasma membrane and implicated that TEMs might act as entry platforms for clathrin - and caveolin-independent entry of HPV16.

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  • One important feature of tetraspanins is their ability to interact laterally with each other and with other transmembrane proteins to form tetraspanin-enriched microdomains

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  • Pion M, Pelchen-Matthews A, Collinson L, Arrighi JF, et al. (2005) HIV-1 trafficking to the dendritic cell-T-cell infectious synapse uses a pathway of tetraspanin sorting to the immunological synapse.

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  • Regarding the inhibitory mechanisms of the antibodies, we have preliminary data showing that treatment of the cells with tetraspanin-specific antibodies results in increased uptake of TEM proteins.

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  • More recently, the tetraspanin CD63 has been identified to be associated with sites of human immunodeficiency virus type 1 (HIV-1) assembly and may be incorporated into viral membranes

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  • Barreiro O, Yanez-Mo M, Sala-Valdes M, Gutierrez-Lopez MD, Ovalle S, et al. (2005) Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation.

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  • Higginbottom A, Partridge LJ, Parthasarathy V, et al. (2006) Recombinant extracellular domains of tetraspanin proteins are potent inhibitors of the infection of macrophages by human immunodeficiency virus type 1.

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