Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Plural form of tetraspanin.

Etymologies

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Examples

  • "We were sort of stumped," Caplan admits, "until we saw a talk that mentioned that tetraspanins like CD82 are associated with exosomes."

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  • Similarly, knockdown of tetraspanins by specific siRNAs may result in reorganization of TEM platforms that are no longer functional for virus entry.

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  • In our study we observed that virions become associated with several tetraspanins including CD63 and CD151 on the cell surface during the invasion process.

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  • Following cell attachment, HPV16 particles colocalized with the tetraspanins CD63 and CD151 on the cell surface.

    PLoS ONE Alerts: New Articles

  • The potential impact of tetraspanins in the process of virus entry is suggested by the observation that CD63-specific antibodies or recombinant extracellular domains of specific tetraspanins can inhibit HIV infection

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  • Similarly, it has been suggested that the tetraspanin CD63 plays a role in the entry process of HIV-1 as it has recently been reported that HIV-1 infection was inhibited by anti-CD63 antibodies and also by recombinant soluble forms of the large extracellular domain of human tetraspanins

    PLoS ONE Alerts: New Articles

  • Instead, we found a close association of virions with the tetraspanins CD63 and CD151 on the cell surface.

    PLoS ONE Alerts: New Articles

  • Which mechanisms are used for endocytosis of tetraspanins from the plasma membrane is not clear.

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  • The molecular basis for the broad functionality of tetraspanins appears to be the capacity to form multiple intermolecular interactions with a large but defined set of transmembrane and intracellular molecules.

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  • HPV16 might act as an important tool to clarify mechanisms and factors involved in uptake of tetraspanins and TEM-associated proteins.

    PLoS ONE Alerts: New Articles

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