Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A sesquiterpene lactone that is an inhibitor of a certain class of enzymes

Etymologies

Sorry, no etymologies found.

Examples

  • To confirm that mTORC1 regulates JNK / c-Jun activation in response to ER stress, we studied the effect of thapsigargin, which is an ER stressor, and that of anisomycin, which activates JNK in an ER stress-independent manner.

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  • Research on interaction of thapsigargin and certain cell membranes.

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  • Three unrelated pharmacological agents (tunicamycin, thapsigargin and brefeldin A) all repressed APP proteolysis in parallel with activation of unfolded protein response (UPR) signaling-a biochemical marker of ER stress.

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  • Co-treatment of the γ-secretase reporter cells with PBA blocked the repressive effects of tunicamycin and thapsigargin upon APP proteolysis, UPR activation, and apoptosis.

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  • * Design and synthesis of SERCA inhibitors base don the pharmacophore of thapsigargin.

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  • This is due to loss of the finite Ca2+ content within the ER and the progressive removal of the ion by plasma membrane ATPases that are insensitive to thapsigargin.

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  • Cells exposed to GSM RF fields at 1 of 7 SARs (0.012, 0.062, 0.125, 0.25, 0.5, 1 or 2 W/kg) for 30 minutes had similar peak thapsigargin-evoked Ca

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  • Addition of extracellular Ca2+ to thapsigargin-treated coverslides induced a large store-operated Ca

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  • There were no significant differences in the time constants for the recovery of thapsigargin-evoked Ca

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  • Bii, RF exposure at a wide range of SARs showed no influence on the thapsigargin-induced peak Ca

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