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- n. Any of a class of cytotoxic antifungal bicyclic peptides isolated from marine sponges of the genus Theonella
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We generated a chemical-genomic profile of theonellamide F using a collection of fission yeast strains in which each open reading frame (ORF) is expressed under the control of an inducible promoter.
Clustering analysis of the Gene Ontology (GO) terms associated with the genes that alter drug sensitivity suggested a mechanistic link between theonellamide and
Subcellular localization and in vitro binding assays using a fluorescent theonellamide derivative revealed that theonellamides specifically bind to 3β-hydroxysterols, including ergosterol, and cause membrane damage.
Now, researchers led by Minoru Yoshida from the RIKEN Advanced Science Institute in Wako, have characterized the biological properties of theonellamide (TNM), an antifungal natural product isolated from marine sponges1.
In vivo imaging reveals the binding sites of theonellamide (TNM), a novel antifungal agent.