Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any of a class of cytotoxic antifungal bicyclic peptides isolated from marine sponges of the genus Theonella

Etymologies

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Examples

  • We generated a chemical-genomic profile of theonellamide F using a collection of fission yeast strains in which each open reading frame (ORF) is expressed under the control of an inducible promoter.

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  • Clustering analysis of the Gene Ontology (GO) terms associated with the genes that alter drug sensitivity suggested a mechanistic link between theonellamide and

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  • Subcellular localization and in vitro binding assays using a fluorescent theonellamide derivative revealed that theonellamides specifically bind to 3β-hydroxysterols, including ergosterol, and cause membrane damage.

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  • Now, researchers led by Minoru Yoshida from the RIKEN Advanced Science Institute in Wako, have characterized the biological properties of theonellamide (TNM), an antifungal natural product isolated from marine sponges1.

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  • In vivo imaging reveals the binding sites of theonellamide (TNM), a novel antifungal agent.

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