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- n. Plural form of theonellamide.
Sorry, no etymologies found.
A.S. prepared the yeast strain collection; S.M. prepared theonellamides.
Subcellular localization and in vitro binding assays using a fluorescent theonellamide derivative revealed that theonellamides specifically bind to 3β-hydroxysterols, including ergosterol, and cause membrane damage.
The biological activity of theonellamides was alleviated in mutants defective in ergosterol biosynthesis.
Here we report the mode of action of theonellamides, bicyclic peptides derived from marine sponges.
Matsunaga, S. & Yoshida, M. Marine antifungal theonellamides target 3β-hydroxysterol to activate Rho1 signalling.