thioesterification love



from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any reaction that leads to the production of a thioester


from Wiktionary, Creative Commons Attribution/Share-Alike License

thio- +‎ esterification


  • E1 conformations "along the path through adenylation and thioesterification could be targeted for therapeutic intervention," they write in

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  • E1-SUMO Interaction E1 (pink and blue) converts from its open to its closed state and then back again as it catalyzes thioesterification of SUMO (yellow) in an adenylated form, which releases an adenine monophosphate group.

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  • But the sites are about 30 Å apart-about 10 times the distance needed for such a transfer to occur. of Sloan-Kettering Institute, in New York City, and coworkers have now solved that problem by designing analogs of the ubiquitin-like protein SUMO that freeze the E1 enzyme during adenylation and thioesterification.

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