Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Either of two dyes (thioflavin S and thioflavin T) used for histology staining and biophysical studies of protein aggregation.

Etymologies

Sorry, no etymologies found.

Examples

  • A defining characteristic of amyloid fibrils and protofibrils is their ability to bind the fluorescent dye thioflavin T (ThT) [63] - [65]

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  • E. coli inclusion bodies, a population of MstnPP spontaneously misfolds into amyloid protofibril-like aggregates that can be visualised using electron microscopy and bind the amyloid-specific dye thioflavin T.

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  • We now show that a human MstnPP misfolded species shares the morphological characteristics of amyloid protofibrils and the ability to bind the amyloid-specific dye thioflavin T.

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  • When MstnPP-containing Escherichia coli inclusion bodies are refolded and purified, a proportion of MstnPP spontaneously misfolds into amyloid-like aggregates as characterised by electron microscopy and binding of the amyloid-specific dye thioflavin T.

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  • Fibril formation was achieved using a continuous in vitro fibrillization assay, with amyloid fibril formation monitored by the dye, thioflavin T (ThT).

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  • These substitutions also result in a dramatic enhancement of both thioflavin-T positive fibril formation and binding to preformed Aβ fibrils while maintaining its plaque-binding ability in AD transgenic mice.

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  • A defining characteristic of amyloid fibrils and protofibrils is their ability to bind the fluorescent dye thioflavin T (ThT) [63] - [65].

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