Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A derivative of guanine obtained by replacing the carbonyl group with a thiol; it is an antineoplastic agent

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • n. an antineoplastic drug used to treat acute leukemias

Etymologies

Sorry, no etymologies found.

Examples

  • Our research was untargeted, and the line of inquiry we had begun in the 1940s yielded new drug therapies for malaria (pyrimethamine), leukemia (6-mercaptopurine and thioguanine), gout (allopurinol), organ transplantation

    George H. Hitchings - Autobiography

  • Stimulated by this finding Elion and Hitchings continued their research which soon resulted in two new chemotherapeutic drugs, thioguanine (1950) and

    Physiology or Medicine 1988 - Press Release

  • Meanwhile, the pursuit of 6-MP, thioguanine, azathioprine and allopurinol had occupied 20 years.

    Nobel Lecture The Purine Path To Chemotherapy

  • We continued to synthesize derivatives of 6-MP and thioguanine and investigate structure-activity relationships (38-40).

    Nobel Lecture The Purine Path To Chemotherapy

  • This lead to the loss of antitumor activity, with the exception of the 2-amino-6-mercapto derivative, thioguanine, which we had previously found to have strong antimetabolic activity.

    Nobel Lecture The Purine Path To Chemotherapy

  • Life-threatening ways and assuming have supported observed as linkages of thioguanine-induced granulocytopenia and thrombocytopenia.

    Wii-volution

  • However, the COG trial with 401 patients enrolled, showed that a thioguanine, procarbazine, lomustine and vincristine (TPCV) regimen was more effective than the CV regimen and resulted in a five-year event-free survival rate of nearly

    WebWire | Recent Headlines

  • The study of 401 patients found that a regimen of thioguanine, procarbazine, lomustine and vincristine (TPCV) was more effective than a carboplatin and vincristine (VC) regimen and achieved a 5-year, event-free survival rate of almost 50 percent.

    Medlogs - Recent stories

  • (as well as thioguanine) are still used in the treatment of leukemia (Table II).

    Physiology or Medicine 1988 - Press Release

  • (particularly by methylthioinosinic acid), inhibition of inosinate dehydrogenase, and the incorporation into DNA in the form of thioguanine (35).

    Nobel Lecture The Purine Path To Chemotherapy

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