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- noun Plural form of
Sorry, no etymologies found.
Arrows on top show positions of threonines 175 and 217 and the disease-causing mutation C212.
We were unable to replicate findings suggesting that phosphorylation of two threonines in a conserved region of Parkin is sufficient to induce Parkin recruitment to mitochondria
On the other hand, the CTD of NFAT5 has a high content of serines (145 residues) and threonines (74 residues), which together comprise more than 22% of this domain, suggesting the possibility of a complex phosphorylation-dependent regulation.
It has been proposed that PINK1 may induce mitochondrial recruitment of Parkin through phosphorylation of threonines 175 and 217 in a highly conserved region/domain of Parkin, which has been recently named RING0 (
Although these findings do not rule out the possibility that phosphorylation of these sites by PINK1 or another kinase induces Parkin recruitment, they suggest that these threonines are more likely to play an important structural role (