Definitions

from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. A white powder, C12H18N2O3S, that lowers the level of sugar in the blood and is used in the treatment of diabetes.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A drug that blocks potassium channels, used in the treatment of diabetes.

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • n. sulfonylurea; an oral antidiabetic drug (trade name Orinase) used in the treatment of adult-onset diabetes mellitus

Etymologies

from The American Heritage® Dictionary of the English Language, 4th Edition

tol(u) + but- + amide.

Examples

  • Metformin and sulfonylurea drugs -- the latter a class of diabetes drugs including glyburide, glipizide, chlorpropamide, tolbutamide and tolazamide -- are often among the first medications prescribed to lower blood sugar levels in people with type 2 diabetes.

    Drug linked to increased risk for older diabetics

  • Data presented indicated that tolbutamide increased cardiovascular deaths by over two and a half times.

    Whole new ball game-case in point Avandia

  • In time, the reputation of the class of diabetic drugs to which tolbutamide belonged was salvaged to some degree by proposing that tolbutamide might interfere with a purported pathophysiologic mechanism called "ischemic preconditioning" while others drugs in this family might not.

    Whole new ball game-case in point Avandia

  • Type 2 diabetes that went through a strikingly similar controversy: tolbutamide.

    NYT > Home Page

  • The headline appeared almost exactly 35 years ago, on July 4, 1975, about a different drug for Type 2 diabetes that went through a strikingly similar controversy: tolbutamide.

    Top Headlines

  • Inform patient that alcohol may react with tolbutamide and cause Antabuse - like reaction (eg, flushing, headache, dizziness, high BP).

    Wii-volution

  • Kangkong showed oral hypoglycaemic activity in tests with diabetic humans and rats; it was shown that an aqueous leaf extract can be as effective as tolbutamide in reducing blood glucose levels

    Find Me A Cure

  • Clinically meaningful interactions would not be expected with other sulfonylureas (e.g., glipizide, tolbutamide, and glimepiride) which, like glyburide, are primarily eliminated by CYP2C9.

    Digital50.com Digital 50 Daily Industry News RSS Feed

  • Clinically meaningful interactions would not be expected with other sulfonylureas (e.g., glipizide, tolbutamide, and glimepiride) which, like glyburide, are primarily eliminated by CYP2C9

    Digital50.com Digital 50 Daily Industry News RSS Feed

  • This reduction in metabolism was also reflected in the in vivo elimination profiles of several drugs, including midazolam, metoprolol, and tolbutamide.

    Journal of Biological Chemistry current issue

Comments

Log in or sign up to get involved in the conversation. It's quick and easy.