tolerizing

Our finding that blockage with anti-HBD (N20, Santa Cruz) did inhibit development of a tolerizing phenotype

PLoS ONE Alerts: New Articles Adi Tabib et al. 2009

Indirectly, as a part of TSP-1, or in its trimeric form, rHBD may influence development of the tolerizing phenotype of DCs following binding of TSP-1.

PLoS ONE Alerts: New Articles Adi Tabib et al. 2009

Here we show that rHBD by itself is not directly responsible for immune paralysis and tolerizing phenotype of DCs, at least in the monomeric form, but has a significant role in rendering DCs phagocytic.

PLoS ONE Alerts: New Articles Adi Tabib et al. 2009

An additional explanation may be a two-step mechanism, for example augmentation of apoptotic cell uptake that leads later to a more pronounced tolerizing phenotype.

PLoS ONE Alerts: New Articles Adi Tabib et al. 2009

Hebrew University and Hadassah University Medical Center, Jerusalem, Israel In our previous study, we have found that thrombospondin-1 (TSP-1) is synthesized de novo upon monocyte and neutrophil apoptosis, leading to a phagocytic and tolerizing phenotype of dendritic cells (DC), even prior to DC-apoptotic cell interaction.

PLoS ONE Alerts: New Articles Adi Tabib et al. 2009

Another possibility is that HBD plays a role in creating the tolerizing phenotype, but only as a part of TSP-1, when a signalosome is formed

PLoS ONE Alerts: New Articles Adi Tabib et al. 2009

In summary, we have shown that rHBD by itself is not directly responsible for immune paralysis and tolerizing phenotype of DCs, at least in the monomeric form, but has a significant role in rendering DCs phagocytic.

PLoS ONE Alerts: New Articles Adi Tabib et al. 2009

Krispin A, Bledi Y, Atallah M, Trahtemberg U, Verbovetski I, et al. (2006) Apoptotic cell thrombospondin-1 and heparin-binding domain lead to dendritic-cell phagocytic and tolerizing states.

PLoS ONE Alerts: New Articles Adi Tabib et al. 2009

We showed earlier that TSP-1 induced a phagocytic and tolerizing state for iDCs

PLoS ONE Alerts: New Articles Adi Tabib et al. 2009

In the current study we were interested to examine the role of HBD in the clearance of apoptotic cells, and whether the phagocytic and tolerizing state of DCs is mediated by the HBD itself, or whether the entire TSP-1 is needed.

PLoS ONE Alerts: New Articles Adi Tabib et al. 2009